these collected pics to make my imagine better about the position. and related and possible complications.
so i found out that in acromegaly, most often due to an adenoma of the pituitary, there is also prolactin excess. why? both GROWTH H AND PROLACTIN ARE FROM THE ACIDOPHILS IN THE PITUITARY
YES YES ONE IMPORTANT POINT TO NOTE, THYROTOXICOSIS CAN LEAD TO OSTEOPOROSIS!!!!!
ok why im stressing this out because when we students say that in thyrotoxicosis there is osteoporosis, one of the residents in the endocrinology dept( btw im in endocrinology dept this week! yeay) denied this statement . so i disagree!( maybe he forgot about it..)
to put it in a simple way, thyroid hormone is essential for skeletal bone development in childhood and for bone preservation through adulthood.
Thyroid hormones are essential for skeletal development and bone maintenance. Childhood hypothyroidism causes growth arrest with delayed bone maturation, whereas thyrotoxicosis accelerates growth and advances bone age. In adults, thyrotoxicosis causes osteoporosis and increased susceptibility to fracture
suck this fact in like a vacuum;
pretibial myxedema is a NON PITTING OEDEMA
IT CAN HAPPEN IN GRAVES DISEASE(late) OR OCCASIONALLY in 1ry hypothyroidism, hashimoto’s thyroiditis
hypertension can happen in acromegaly
Growth hormone has antinatriuretic actions and may lead to sodium retention and volume expansion
to understand the pathophysiology of diseases , first and foremost , we need to study the normal .
vit d is carried ( by albumin and proteun carriers) to the liver–> inactive form
then to the kidneys where it is transformed into the active form by wn enzyme here.
PTH increase the production of the actve form of vitamin d(calcitriol) by forming the enzyme required for that transformation(25(OH)vitamin D-1α-hydroxylase).
calcitriol will in turn increase absorption of calcium from the small intestine.
other actions of PTH:
increase Ca reabsorption
increase RESORPTION FROM BONES(get out of the bones calcium!!)
increase phosphate excretion
well basically PTH WANTS TO INCREASE THE SERUM CALCIUM.
pssst!!! in renal failure there is lack of prodcution of calcitriol!!! alert: HYPOCALCEMIA, which may be corrected by 2ry hyperparathyroidism
you know whats primary(tumours) and secondary( physiological response to hypocalcemia) .
but what about tertiary??
it is the development of autonomous(doesnt respect the feedback mechanism and keeps secreting PTH) parathyroid hyperplasia AFTER LONG STANDING 2RY HYPERPARWTHYROIDISM( most often in renal failure.
clinical manifestation? —– of hypercalcemia
why is there an increase in urinary cAMP in primary hyperparathyroidism?
The posterior pituitary does not produce its own hormones. rather, hornones are stored here(oxytocin and vasopressin) .they are produced by the hypothalamus.
pituitary function is assessed by the target gland function, not by measuring the pituitary hormone as an isolated event. This is in contrast to target gland function being assessed by the pituitary hormone
kallmans syndrome is isolated decrease in GnRH + anosmia
in pregnancy pituitary gland is enlarged. when postpartum hge happens this leads to ischemic pituitary necrosis.SHEEHAN’S SYNDROME
Adrenocorticotropic hormone, as its name implies, stimulates the adrenal cortex. More specifically, it stimulates secretion of glucocorticoids such as cortisol, and has little control over secretion of aldosterone, the other major steroid hormone from the adrenal cortex.
i always forget this!!!!!!
low blood glucose stimulates production of growth hormones!!! hence insulin stimulation test causes increase GH IN NORMAL PPL AND GH IS NOT ELEVATED IN THIS CASE!! in hypopituitarism that iss…
ACTH is produced in a process that also generates several other hormones
The major attributes of the hormones other than ACTH that are produced in this process are summarized as follows:
Lipotropin: Originally described as having weak lipolytic effects, its major importance is as the precursor to beta-endorphin.
Beta-endorphin and Met-enkephalin: Opioid peptides with pain-alleviation and euphoric effects.(SUBHANALLAH.ALLAH CREATED INNER PAIN RELIEVERS FOR US HUMANS! syukurillah)
Melanocyte-stimulating hormone (MSH): Known to control melanin pigmentation in the skin of most vertebrates.(take note!!!!! in absence of acth, this process is diminished thus DEPIGMENTATION OCCURS IN ARESS NORMALLY PIGMENTED eg; areola)
psssst: kontot notes. will be updated in the future. OSCE ALARM: 3 MORE DAYS IM RUNNING OUT OF TIME STOP PROCRASTINATING.
lillahitaala! itqan fil ‘amal
for the pleasure of my eyes:
normal mri of pituitary gland. oh my cute lil pituitary looking like an edible M&m.
empty sella synd.